Endocrine Abstracts

AIMS: The Pituitary Foundation (a national UK Support Group)undertook a questionnaire of its members to solicit patients' views on their experience of growth hormone replacement (GHR). This resulted in a lay submission to NICE regarding GHR in adults.METHOD: A questionnaire was mailed to members known to be receiving GHR. 78% of these (303) were returned. In addition, a further 86 completed questionnaires were received following a...

CRF mediates numerous complementary stress-related endocrine (HPA), autonomic and behavioral responses. CRF antagonists block many stress-induced responses in experimental animals. Furthermore, perturbations of the CRF system or HPA have been reported in human affective disorders. CRF acts through two Class B G protein coupled receptors derived from two genes, which have alternative splice variants and distinct expression patterns. Mice null for CRF-R1 exhibit reduced basal an...

Introduction: Pituitary incidentalomas (PIs) defined as pituitary tumors discovered by systematic neuroimaging constitute an increasingly clinical problem. Most of PIs are nonfunctioning tumors (NFPIs) with systematic investigation revealing visual and/or endocrinological impairment in some patients while others remained asymptomatic. If the therapeutic management is well codified for functioning PIs and symptomatic NFPIs, a debate still remain for asymptomatic NFPIs between s...